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8jr1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with TBAJ-587== | |
| - | + | <StructureSection load='8jr1' size='340' side='right'caption='[[8jr1]], [[Resolution|resolution]] 3.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jr1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JR1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UTI:(1~{S},2~{S})-1-(6-bromanyl-2-methoxy-quinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoranyl-3-methoxy-phenyl)butan-2-ol'>UTI</scene></td></tr> |
| - | [[Category: Gong | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jr1 OCA], [https://pdbe.org/8jr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jr1 RCSB], [https://www.ebi.ac.uk/pdbsum/8jr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jr1 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Liu | + | == Function == |
| - | [[Category: Rao | + | [https://www.uniprot.org/uniprot/A0A045H4W8_MYCTX A0A045H4W8_MYCTX] F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.[ARBA:ARBA00025198][HAMAP-Rule:MF_01396] Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.[HAMAP-Rule:MF_01396] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Gong H]] | ||
| + | [[Category: Lai Y]] | ||
| + | [[Category: Liu F]] | ||
| + | [[Category: Rao Z]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with TBAJ-587
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Categories: Large Structures | Mycobacterium tuberculosis | Gong H | Lai Y | Liu F | Rao Z | Zhang Y
