This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8pvi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8pvi is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of PaaZ determined by cryoEM at 100 keV== | |
| - | + | <StructureSection load='8pvi' size='340' side='right'caption='[[8pvi]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pvi OCA], [https://pdbe.org/8pvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pvi RCSB], [https://www.ebi.ac.uk/pdbsum/8pvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pvi ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cannone G]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Dalby J]] | ||
| + | [[Category: Dickerson JL]] | ||
| + | [[Category: El-Gomati MM]] | ||
| + | [[Category: Gittins O]] | ||
| + | [[Category: Henderson R]] | ||
| + | [[Category: Hutchings KA]] | ||
| + | [[Category: Lee Y]] | ||
| + | [[Category: McMullan G]] | ||
| + | [[Category: Meffert M]] | ||
| + | [[Category: Mihaylov D]] | ||
| + | [[Category: Naydenova K]] | ||
| + | [[Category: Peet MJ]] | ||
| + | [[Category: Russo CJ]] | ||
| + | [[Category: Schulze-Briese C]] | ||
| + | [[Category: Sobhy M]] | ||
| + | [[Category: Wells T]] | ||
| + | [[Category: Wilson H]] | ||
| + | [[Category: Yamashita K]] | ||
Current revision
Structure of PaaZ determined by cryoEM at 100 keV
| |||||||||||
Categories: Escherichia coli | Large Structures | Cannone G | Chen S | Dalby J | Dickerson JL | El-Gomati MM | Gittins O | Henderson R | Hutchings KA | Lee Y | McMullan G | Meffert M | Mihaylov D | Naydenova K | Peet MJ | Russo CJ | Schulze-Briese C | Sobhy M | Wells T | Wilson H | Yamashita K
