8pvi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of PaaZ determined by cryoEM at 100 keV== | |
| - | + | <StructureSection load='8pvi' size='340' side='right'caption='[[8pvi]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pvi OCA], [https://pdbe.org/8pvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pvi RCSB], [https://www.ebi.ac.uk/pdbsum/8pvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pvi ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cannone G]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Dalby J]] | ||
| + | [[Category: Dickerson JL]] | ||
| + | [[Category: El-Gomati MM]] | ||
| + | [[Category: Gittins O]] | ||
| + | [[Category: Henderson R]] | ||
| + | [[Category: Hutchings KA]] | ||
| + | [[Category: Lee Y]] | ||
| + | [[Category: McMullan G]] | ||
| + | [[Category: Meffert M]] | ||
| + | [[Category: Mihaylov D]] | ||
| + | [[Category: Naydenova K]] | ||
| + | [[Category: Peet MJ]] | ||
| + | [[Category: Russo CJ]] | ||
| + | [[Category: Schulze-Briese C]] | ||
| + | [[Category: Sobhy M]] | ||
| + | [[Category: Wells T]] | ||
| + | [[Category: Wilson H]] | ||
| + | [[Category: Yamashita K]] | ||
Current revision
Structure of PaaZ determined by cryoEM at 100 keV
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Categories: Escherichia coli | Large Structures | Cannone G | Chen S | Dalby J | Dickerson JL | El-Gomati MM | Gittins O | Henderson R | Hutchings KA | Lee Y | McMullan G | Meffert M | Mihaylov D | Naydenova K | Peet MJ | Russo CJ | Schulze-Briese C | Sobhy M | Wells T | Wilson H | Yamashita K
