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Cytochrome P450
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== Function == | == Function == | ||
| - | [[Cytochrome P450]] (P450) or '''cytochrome P450 monooxygenase''' catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> | + | [[Cytochrome P450]] (P450) or '''cytochrome P450 monooxygenase''' catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> P450 CYP121 is called '''mycocyclosin synthase'''. |
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br /> | * '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br /> | ||
* '''P450nor''' is a Nitric Oxide Reductase P450.<br /> | * '''P450nor''' is a Nitric Oxide Reductase P450.<br /> | ||
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* '''P450 3A4''' see [[CYP3A4]].<br /> | * '''P450 3A4''' see [[CYP3A4]].<br /> | ||
* '''P450 19 family''' see [[Aromatase]].<br /> | * '''P450 19 family''' see [[Aromatase]].<br /> | ||
| - | + | * '''P450 17A1''' see [[Abiraterone acetate|Human steroidogenic cytochrome P450 17A1 with inhibitor abiraterone]] | |
See also [[Hemeproteins]]. | See also [[Hemeproteins]]. | ||
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*[[Montelukast]] - anti rhinitis | *[[Montelukast]] - anti rhinitis | ||
*[[Noxafil]] - antifungal drug which binds to CYP51. | *[[Noxafil]] - antifungal drug which binds to CYP51. | ||
| + | *[[Cobicistat]] - anti HIV/AIDS drug which binds to CYP3A4. | ||
== Structural highlights == | == Structural highlights == | ||
Current revision
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References
- ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
- ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862
