8th8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Linker domain of Nexin-dynein regulatory complex from Tetrahymena thermophila== | |
| + | <StructureSection load='8th8' size='340' side='right'caption='[[8th8]], [[Resolution|resolution]] 7.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8th8]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TH8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8th8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8th8 OCA], [https://pdbe.org/8th8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8th8 RCSB], [https://www.ebi.ac.uk/pdbsum/8th8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8th8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q229S1_TETTS Q229S1_TETTS] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacent doublet microtubules and regulates and coordinates the activity of outer doublet complexes. Despite its critical role in cilia motility, the assembly and molecular basis of the regulatory mechanism are poorly understood. Here, using cryo-electron microscopy in conjunction with biochemical cross-linking and integrative modeling, we localize 12 DRC subunits in the N-DRC structure of Tetrahymena thermophila. We also find that the CCDC96/113 complex is in close contact with the DRC9/10 in the linker region. In addition, we reveal that the N-DRC is associated with a network of coiled-coil proteins that most likely mediates N-DRC regulatory activity. | ||
| - | + | Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism.,Ghanaeian A, Majhi S, McCafferty CL, Nami B, Black CS, Yang SK, Legal T, Papoulas O, Janowska M, Valente-Paterno M, Marcotte EM, Wloga D, Bui KH Nat Commun. 2023 Sep 15;14(1):5741. doi: 10.1038/s41467-023-41480-7. PMID:37714832<ref>PMID:37714832</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8th8" style="background-color:#fffaf0;"></div> |
| - | [[Category: Bui | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tetrahymena thermophila]] | ||
| + | [[Category: Bui KH]] | ||
| + | [[Category: Ghanaeian AG]] | ||
Current revision
Linker domain of Nexin-dynein regulatory complex from Tetrahymena thermophila
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