1ls8

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[[Image:1ls8.gif|left|200px]]
 
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==NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH==
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The line below this paragraph, containing "STRUCTURE_1ls8", creates the "Structure Box" on the page.
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<StructureSection load='1ls8' size='340' side='right'caption='[[1ls8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ls8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LS8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ls8 OCA], [https://pdbe.org/1ls8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ls8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ls8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ls8 ProSAT]</span></td></tr>
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{{STRUCTURE_1ls8| PDB=1ls8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PBP_BOMMO PBP_BOMMO] This major soluble protein in olfactory sensilla of male moths serves to solubilize the extremely hydrophobic pheromone molecules such as bombykol and to transport pheromone through the aqueous lymph to receptors located on olfactory cilia.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1ls8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ls8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nuclear magnetic resonance structure of the unliganded pheromone-binding protein (PBP) from Bombyx mori at pH above 6.5, BmPBP(B), consists of seven helices with residues 3-8, 16-22, 29-32, 46-59, 70-79, 84-100, and 107-124, and contains the three disulfide bridges 19-54, 50-108, and 97-117. This polypeptide fold encloses a large hydrophobic cavity, with a sufficient volume to accommodate the natural ligand bombykol. The polypeptide folds in free BmPBP(B) and in crystals of a BmPBP-bombykol complex are nearly identical, indicating that the B-form of BmPBP in solution represents the active conformation for ligand binding.
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'''NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH'''
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NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH.,Lee D, Damberger FF, Peng G, Horst R, Guntert P, Nikonova L, Leal WS, Wuthrich K FEBS Lett. 2002 Nov 6;531(2):314-8. PMID:12417333<ref>PMID:12417333</ref>
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==Overview==
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The nuclear magnetic resonance structure of the unliganded pheromone-binding protein (PBP) from Bombyx mori at pH above 6.5, BmPBP(B), consists of seven helices with residues 3-8, 16-22, 29-32, 46-59, 70-79, 84-100, and 107-124, and contains the three disulfide bridges 19-54, 50-108, and 97-117. This polypeptide fold encloses a large hydrophobic cavity, with a sufficient volume to accommodate the natural ligand bombykol. The polypeptide folds in free BmPBP(B) and in crystals of a BmPBP-bombykol complex are nearly identical, indicating that the B-form of BmPBP in solution represents the active conformation for ligand binding.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1LS8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS8 OCA].
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</div>
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<div class="pdbe-citations 1ls8" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH., Lee D, Damberger FF, Peng G, Horst R, Guntert P, Nikonova L, Leal WS, Wuthrich K, FEBS Lett. 2002 Nov 6;531(2):314-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12417333 12417333]
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*[[Odorant binding protein|Odorant binding protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bombyx mori]]
[[Category: Bombyx mori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Damberger, F.]]
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[[Category: Damberger F]]
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[[Category: Guntert, P.]]
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[[Category: Guntert P]]
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[[Category: Horst, R.]]
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[[Category: Horst R]]
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[[Category: Leal, W S.]]
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[[Category: Leal WS]]
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[[Category: Lee, D.]]
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[[Category: Lee D]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: Bmpbp]]
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[[Category: Bmpbpb]]
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[[Category: Nmr]]
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[[Category: Pheromone binding protein]]
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[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:14:10 2008''
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Current revision

NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH

PDB ID 1ls8

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