8k8b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a hairpin RNA with the UUCGA loop== | |
| + | <StructureSection load='8k8b' size='340' side='right'caption='[[8k8b]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8k8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K8B FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8b OCA], [https://pdbe.org/8k8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8b RCSB], [https://www.ebi.ac.uk/pdbsum/8k8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop. | ||
| - | + | NMR analysis of a loop-bulge structure of UUCGA pentaloop.,Ichijo R, Kawai G Biochem Biophys Res Commun. 2024 Jan 8;691:149327. doi: , 10.1016/j.bbrc.2023.149327. Epub 2023 Nov 25. PMID:38039839<ref>PMID:38039839</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Ichijo | + | <div class="pdbe-citations 8k8b" style="background-color:#fffaf0;"></div> |
| - | [[Category: Kawai | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ichijo R]] | ||
| + | [[Category: Kawai G]] | ||
Current revision
Solution structure of a hairpin RNA with the UUCGA loop
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