8k8j

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'''Unreleased structure'''
 
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The entry 8k8j is ON HOLD
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==Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex==
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<StructureSection load='8k8j' size='340' side='right'caption='[[8k8j]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8k8j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K8J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J3O:propan-2-yl+2-[4-(4-chlorophenyl)carbonylphenoxy]-2-methyl-propanoate'>J3O</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8j OCA], [https://pdbe.org/8k8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8j RCSB], [https://www.ebi.ac.uk/pdbsum/8k8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8j ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The G-protein-coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1-G(i) complexes in synthetic agonist-bound forms have been resolved to date. However, the commercial drug recognition and G(q) coupling mechanisms of CB1 remain elusive. Herein, the cryo-electron microscopy (cryo-EM) structure of CB1-G(q) complex, in fenofibrate-bound form, at near-atomic resolution, is reported. The structure elucidates the delicate mechanisms of the precise fenofibrate recognition and G(q) protein coupling by CB1 and will facilitate future drug discovery and design.
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Authors:
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Fenofibrate Recognition and G(q) Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1.,Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F, Wang J Adv Sci (Weinh). 2024 Apr;11(14):e2306311. doi: 10.1002/advs.202306311. Epub 2024 , Jan 31. PMID:38298116<ref>PMID:38298116</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8k8j" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li FH]]
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[[Category: Tang WQ]]
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[[Category: Wang JY]]
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[[Category: Wang TX]]

Current revision

Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex

PDB ID 8k8j

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