8kb8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the WDR91 WD40 domain complexed with Rab7== | |
| - | + | <StructureSection load='8kb8' size='340' side='right'caption='[[8kb8]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8kb8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KB8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kb8 OCA], [https://pdbe.org/8kb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kb8 RCSB], [https://www.ebi.ac.uk/pdbsum/8kb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kb8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Banerjee S]] | ||
| + | [[Category: Dong ZG]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Ma XL]] | ||
Current revision
Structure of the WDR91 WD40 domain complexed with Rab7
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Categories: Homo sapiens | Large Structures | Banerjee S | Dong ZG | Li J | Ma XL
