8kc3
From Proteopedia
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(New page: '''Unreleased structure''' The entry 8kc3 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human C-terminally bound ATG9A-ATG2A-WIPI4 complex== | |
| - | + | <StructureSection load='8kc3' size='340' side='right'caption='[[8kc3]], [[Resolution|resolution]] 7.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8kc3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KC3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kc3 OCA], [https://pdbe.org/8kc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kc3 RCSB], [https://www.ebi.ac.uk/pdbsum/8kc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kc3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATG9A_HUMAN ATG9A_HUMAN] Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.<ref>PMID:16940348</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Stjepanovic G]] | ||
| + | [[Category: Wang Y]] | ||
Current revision
Cryo-EM structure of human C-terminally bound ATG9A-ATG2A-WIPI4 complex
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