1m0g

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[[Image:1m0g.jpg|left|200px]]
 
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==Solution structure of the alpha domain of mt_nc==
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The line below this paragraph, containing "STRUCTURE_1m0g", creates the "Structure Box" on the page.
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<StructureSection load='1m0g' size='340' side='right'caption='[[1m0g]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M0G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_1m0g| PDB=1m0g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m0g OCA], [https://pdbe.org/1m0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m0g RCSB], [https://www.ebi.ac.uk/pdbsum/1m0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m0g ProSAT]</span></td></tr>
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</table>
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'''Solution structure of the alpha domain of mt_nc'''
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== Function ==
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[https://www.uniprot.org/uniprot/MTA_NOTNE MTA_NOTNE] Metallothioneins have a high content of cysteine residues that bind various heavy metals.
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<div style="background-color:#fffaf0;">
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==Overview==
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== Publication Abstract from PubMed ==
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins.
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins.
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==About this Structure==
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Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps.,Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA Structure. 2003 Apr;11(4):435-43. PMID:12679021<ref>PMID:12679021</ref>
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1M0G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679021 12679021]
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</div>
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<div class="pdbe-citations 1m0g" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Notothenia coriiceps]]
[[Category: Notothenia coriiceps]]
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[[Category: Single protein]]
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[[Category: Capasso C]]
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[[Category: Capasso, C.]]
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[[Category: Carginale V]]
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[[Category: Carginale, V.]]
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[[Category: Crescenzi O]]
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[[Category: Crescenzi, O.]]
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[[Category: Di Maro D]]
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[[Category: Maro, D Di.]]
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[[Category: Parisi E]]
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[[Category: Parisi, E.]]
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[[Category: Spadaccini R]]
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[[Category: Spadaccini, R.]]
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[[Category: Temussi PA]]
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[[Category: Temussi, P A.]]
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[[Category: Cadmium-thiolate cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:29:00 2008''
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Current revision

Solution structure of the alpha domain of mt_nc

PDB ID 1m0g

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