1m1c

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[[Image:1m1c.jpg|left|200px]]
 
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==Structure of the L-A virus==
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The line below this paragraph, containing "STRUCTURE_1m1c", creates the "Structure Box" on the page.
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<StructureSection load='1m1c' size='340' side='right'caption='[[1m1c]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_virus_L-A Saccharomyces cerevisiae virus L-A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1c OCA], [https://pdbe.org/1m1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1c RCSB], [https://www.ebi.ac.uk/pdbsum/1m1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1c ProSAT]</span></td></tr>
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{{STRUCTURE_1m1c| PDB=1m1c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_SCVLA GAG_SCVLA] Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 40 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref> Binds and removes 5' cap structures from cellular mRNA. Forms a covalent bond with m7GMP through His-154 of the capsid protein while releasing the mRNA body.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1c ConSurf].
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<div style="clear:both"></div>
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'''Structure of the L-A virus'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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==Overview==
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<references/>
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The structure of the yeast L-A virus was determined by X-ray crystallography at 3.4 A resolution. The L-A dsRNA virus is 400 A in diameter and contains a single protein shell of 60 asymmetric dimers of the coat protein, a feature common among the inner protein shells of dsRNA viruses and probably related to their unique mode of transcription and replication. The two identical subunits in each dimer are in non-equivalent environments and show substantially different conformations in specific surface regions. The L-A virus decaps cellular mRNA to efficiently translate its own uncapped mRNA. Our structure reveals a trench at the active site of the decapping reaction and suggests a role for nearby residues in the reaction.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1M1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA].
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[[Category: Saccharomyces cerevisiae virus L-A]]
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[[Category: Canady M]]
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==Reference==
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[[Category: Johnson JE]]
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L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism., Naitow H, Tang J, Canady M, Wickner RB, Johnson JE, Nat Struct Biol. 2002 Oct;9(10):725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12244300 12244300]
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[[Category: Naitow H]]
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[[Category: Single protein]]
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[[Category: Tang J]]
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[[Category: Viruses]]
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[[Category: Wickner RB]]
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[[Category: Canady, M.]]
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[[Category: Johnson, J E.]]
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[[Category: Naitow, H.]]
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[[Category: Tang, J.]]
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[[Category: Wickner, R B.]]
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[[Category: Dsrna virus structure]]
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[[Category: Icosahedral virus]]
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[[Category: L-a virus]]
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[[Category: Mrna decapping]]
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[[Category: Quai-equivalence]]
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[[Category: Rna-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:30:44 2008''
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Current revision

Structure of the L-A virus

PDB ID 1m1c

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