1m44

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:39, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m44.gif|left|200px]]
 
-
<!--
+
==Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure==
-
The line below this paragraph, containing "STRUCTURE_1m44", creates the "Structure Box" on the page.
+
<StructureSection load='1m44' size='340' side='right'caption='[[1m44]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1m44]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M44 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1m44| PDB=1m44 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m44 OCA], [https://pdbe.org/1m44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m44 RCSB], [https://www.ebi.ac.uk/pdbsum/1m44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m44 ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/AAC2_MYCTU AAC2_MYCTU] Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. It confers resistance to aminoglycosides.
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
AAC(2')-Ic catalyzes the coenzyme A (CoA)-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. The crystal structure of the AAC(2')-Ic from Mycobacterium tuberculosis has been determined in the apo enzyme form and in ternary complexes with CoA and either tobramycin, kanamycin A or ribostamycin, representing the first structures of an aminoglycoside acetyltransferase bound to a drug. The overall fold of AAC(2')-Ic places it in the GCN5-related N-acetyltransferase (GNAT) superfamily. Although the physiological function of AAC(2')-Ic is uncertain, a structural analysis of these high-affinity aminoglycoside complexes suggests that the enzyme may acetylate a key biosynthetic intermediate of mycothiol, the major reducing agent in mycobacteria, and participate in the regulation of cellular redox potential.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m44_consurf.spt"</scriptWhenChecked>
-
1M44 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M44 OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates., Vetting MW, Hegde SS, Javid-Majd F, Blanchard JS, Roderick SL, Nat Struct Biol. 2002 Sep;9(9):653-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12161746 12161746]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m44 ConSurf].
-
[[Category: Mycobacterium tuberculosis]]
+
<div style="clear:both"></div>
-
[[Category: Single protein]]
+
__TOC__
-
[[Category: Blanchard, J S.]]
+
</StructureSection>
-
[[Category: Hegde, S S.]]
+
[[Category: Large Structures]]
-
[[Category: Javid-Majd, F.]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Roderick, S L.]]
+
[[Category: Blanchard JS]]
-
[[Category: Vetting, M W.]]
+
[[Category: Hegde SS]]
-
[[Category: Coa binding motif]]
+
[[Category: Javid-Majd F]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:36:15 2008''
+
[[Category: Roderick SL]]
 +
[[Category: Vetting MW]]

Current revision

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure

PDB ID 1m44

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m44"
Personal tools