Nucleoside triphosphatase

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<StructureSection load='4a5a' size='350' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry [[4a5a]])' scene=''>
<StructureSection load='4a5a' size='350' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry [[4a5a]])' scene=''>
== Function ==
== Function ==
'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
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*'''Nucleoside triphosphatase Nudi''' catalyses the hydrolysis of preferentially dUTP, dTTP and dCTP.
== Relevance ==
== Relevance ==
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*<snapshot name='84/844927/Cv1/6'>Test2</snapshot>
*<snapshot name='84/844927/Cv1/6'>Test2</snapshot>
*<snapshot name='84/844927/Cv1/8'>Test3</snapshot>
*<snapshot name='84/844927/Cv1/8'>Test3</snapshot>
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</SX>
 
==3D structures of nucleoside triphosphatase==
==3D structures of nucleoside triphosphatase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Nucleoside triphosphatase 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Nucleoside triphosphatase 1
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**[[4a57]] - TgNTPase 1 - ''Toxoplasma gondii'' <br />
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**[[4a59]] - TgNTPase 1 + AMP<br />
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*Nucleoside triphosphatase 2
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**[[4jep]] - TgNTPase 2 <br />
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**[[4a5b]] - TgNTPase 2 (mutant)<br />
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**[[4kh4]], [[4a5a]] - TgNTPase 2 (mutant) + AMPPNP<br />
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**[[4kh5]], [[4kh6]] - TgNTPase 2 (mutant) + AMPNP<br />
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*Nucleoside triphosphatase Nudi
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**[[6dt3]] - Nudi - ''Klebsiella pneumoniae'' <br />
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**[[3oga]], [[3n77]] - Nudi - ''Salmonella enterica'' <br />
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*Nucleoside triphosphatase cancer-related
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**[[2i3b]] - NTPase - human- NMR <br />
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*Nucleoside triphosphatase
 
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**[[3s86]] - NTPase - ''Thermotoga maritima'' <br />
 
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**[[3agr]] - NTPase - ''Neospora caninum'' <br />
 
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**[[7aoh]] - NTPase I in transcribing complex - Vaccinia virus – Cryo EM <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry 4a5a)

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Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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