Peptidyl-tRNA hydrolase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | + | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability.rew)]]. |
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| + | See also [[Peptidyl-tRNA hydrolase 2, mitochondrial (Hebrew)]]. | ||
== Structural highlights == | == Structural highlights == | ||
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*Peptidyl-tRNA hydrolase | *Peptidyl-tRNA hydrolase | ||
| + | **[[1q7s]] – hPTH residues 63-179– human<BR /> | ||
**[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | **[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | ||
**[[3ofv]] – EcPTH (mutant)<BR /> | **[[3ofv]] – EcPTH (mutant)<BR /> | ||
Current revision
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3D Structures of peptidyl-tRNA hydrolase
Updated on 05-January-2025
References
- ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
- ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790
