8ke7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation== | |
| - | + | <StructureSection load='8ke7' size='340' side='right'caption='[[8ke7]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ke7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KE7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ke7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ke7 OCA], [https://pdbe.org/8ke7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ke7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ke7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ke7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chan NL]] | ||
| + | [[Category: Chen SF]] | ||
| + | [[Category: Liu KT]] | ||
Current revision
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation
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