8tva
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8tva is ON HOLD Authors: Meng, R., Xing, Z., Thongchol, J., Zhang, J. Description: outer Mat-T4P complex Category: Unreleased Structures [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Outer Mat-T4P complex== | |
| + | <StructureSection load='8tva' size='340' side='right'caption='[[8tva]], [[Resolution|resolution]] 8.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8tva]] is a 41 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_higginsii Acinetobacter higginsii] and [https://en.wikipedia.org/wiki/Acinetobacter_phage_AP205 Acinetobacter phage AP205]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TVA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.55Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tva OCA], [https://pdbe.org/8tva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tva RCSB], [https://www.ebi.ac.uk/pdbsum/8tva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tva ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Acinetobacters pose a significant threat to human health, especially those with weakened immune systems. Type IV pili of acinetobacters play crucial roles in virulence and antibiotic resistance. Single-stranded RNA bacteriophages target the bacterial retractile pili, including type IV. Our study delves into the interaction between Acinetobacter phage AP205 and type IV pili. Using cryo-electron microscopy, we solve structures of the AP205 virion with an asymmetric dimer of maturation proteins, the native Acinetobacter type IV pili bearing a distinct post-translational pilin cleavage, and the pili-bound AP205 showing its maturation proteins adapted to pilin modifications, allowing each phage to bind to one or two pili. Leveraging these results, we develop a 20-kilodalton AP205-derived protein scaffold targeting type IV pili in situ, with potential for research and diagnostics. | ||
| - | + | Structural basis of Acinetobacter type IV pili targeting by an RNA virus.,Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J Nat Commun. 2024 Mar 29;15(1):2746. doi: 10.1038/s41467-024-47119-5. PMID:38553443<ref>PMID:38553443</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8tva" style="background-color:#fffaf0;"></div> |
| - | [[Category: Thongchol | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Acinetobacter higginsii]] | ||
| + | [[Category: Acinetobacter phage AP205]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Meng R]] | ||
| + | [[Category: Thongchol J]] | ||
| + | [[Category: Xing Z]] | ||
| + | [[Category: Zhang J]] | ||
Current revision
Outer Mat-T4P complex
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