8ihm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Eaf3 CHD domain bound to the nucleosome== | |
| - | + | <StructureSection load='8ihm' size='340' side='right'caption='[[8ihm]], [[Resolution|resolution]] 3.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ihm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IHM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.58Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ihm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ihm OCA], [https://pdbe.org/8ihm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ihm RCSB], [https://www.ebi.ac.uk/pdbsum/8ihm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ihm ProSAT]</span></td></tr> |
| - | [[Category: Gang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Gang C]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Eaf3 CHD domain bound to the nucleosome
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