8q96
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line== | |
| - | + | <StructureSection load='8q96' size='340' side='right'caption='[[8q96]], [[Resolution|resolution]] 3.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q96]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q96 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q96 OCA], [https://pdbe.org/8q96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q96 RCSB], [https://www.ebi.ac.uk/pdbsum/8q96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q96 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Lavenir | + | [https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease. |
| - | [[Category: | + | == Function == |
| - | [[Category: Murzin | + | [https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Crowther RA]] | ||
| + | [[Category: Goedert M]] | ||
| + | [[Category: Lavenir I]] | ||
| + | [[Category: Macdonald J]] | ||
| + | [[Category: Murzin AG]] | ||
| + | [[Category: Scheres SHW]] | ||
| + | [[Category: Schweighauser M]] | ||
Current revision
P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line
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