1mhe

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(New page: 200px<br /> <applet load="1mhe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mhe, resolution 2.85&Aring;" /> '''THE HUMAN NON-CLASS...)
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[[Image:1mhe.gif|left|200px]]<br />
 
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<applet load="1mhe" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mhe, resolution 2.85&Aring;" />
 
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'''THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E'''<br />
 
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==Overview==
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==THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E==
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The crystal structure of the nonclassical human class lb MHC molecule, HLA-E has been determined in complex with a prototypic ligand, the nonamer, peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of, the human MHC class la leader sequence. The mode of peptide binding, retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific, binding to a tightly defined set of almost identical hydrophobic peptides, from the highly conserved class l leader sequences. These molecular, adaptations make HLA-E a rigorous checkpoint at the cell surface reporting, on the integrity of the antigen processing pathway to CD94/NKG2, receptor-bearing natural killer cells.
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<StructureSection load='1mhe' size='340' side='right'caption='[[1mhe]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mhe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhe OCA], [https://pdbe.org/1mhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhe RCSB], [https://www.ebi.ac.uk/pdbsum/1mhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HLAE_HUMAN HLAE_HUMAN] Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mhe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mhe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the nonclassical human class lb MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class l leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells.
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==Disease==
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Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.,O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY Mol Cell. 1998 Mar;1(4):531-41. PMID:9660937<ref>PMID:9660937</ref>
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Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1MHE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MHE OCA].
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</div>
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<div class="pdbe-citations 1mhe" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E., O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY, Mol Cell. 1998 Mar;1(4):531-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9660937 9660937]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bell, J.I.]]
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[[Category: Bell JI]]
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[[Category: Braud, V.B.]]
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[[Category: Braud VB]]
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[[Category: Callaghan, C.A.O.]]
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[[Category: Jakobsen BK]]
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[[Category: Jakobsen, B.K.]]
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[[Category: Jones EY]]
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[[Category: Jones, E.Y.]]
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[[Category: Mcmichael AJ]]
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[[Category: Mcmichael, A.J.]]
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[[Category: O'Callaghan CA]]
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[[Category: Stuart, D.I.]]
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[[Category: Stuart DI]]
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[[Category: Tormo, J.]]
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[[Category: Tormo J]]
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[[Category: Willcox, B.E.]]
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[[Category: Willcox BE]]
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[[Category: SO4]]
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[[Category: beta 2 microglobulin]]
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[[Category: class ib mhc]]
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[[Category: hla]]
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[[Category: hla e]]
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[[Category: hla-e]]
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[[Category: leader peptide]]
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[[Category: major histocompatibility complex]]
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[[Category: mhc]]
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[[Category: non-classical mhc]]
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[[Category: peptide]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:11:16 2007''
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Current revision

THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E

PDB ID 1mhe

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