8ty6

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(New page: '''Unreleased structure''' The entry 8ty6 is ON HOLD Authors: Piacentini, J., Pornillos, O., Ganser-Pornillos, B.K. Description: Disulfide-stabilized HIV-1 CA hexamer in complex with P...)
Current revision (14:55, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ty6 is ON HOLD
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==Disulfide-stabilized HIV-1 CA hexamer in complex with PQBP1 Nt==
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<StructureSection load='8ty6' size='340' side='right'caption='[[8ty6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ty6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TY6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ty6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ty6 OCA], [https://pdbe.org/8ty6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ty6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ty6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ty6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human immunodeficiency virus type 1 (HIV-1) stimulates innate immune responses upon infection, including cyclic GMP-AMP synthase (cGAS) signaling that results in type I interferon production. HIV-1-induced activation of cGAS requires the host cell factor polyglutamine binding protein 1 (PQBP1), an intrinsically disordered protein that bridges capsid recognition and cGAS recruitment. However, the molecular details of PQBP1 interactions with the HIV-1 capsid and their functional implications remain poorly understood. Here, we show that PQBP1 binds to HIV-1 capsids through charge complementing contacts between acidic residues in the N-terminal region of PQBP1 and an arginine ring in the central channel of the HIV-1 CA hexamer that makes up the viral capsid. These studies reveal the molecular details of PQBP1's primary interaction with the HIV-1 capsid and suggest that additional elements are likely to contribute to stable capsid binding.
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Authors: Piacentini, J., Pornillos, O., Ganser-Pornillos, B.K.
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Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice.,Piacentini J, Allen DS, Ganser-Pornillos BK, Chanda SK, Yoh SM, Pornillos O J Mol Biol. 2024 Feb 15;436(4):168409. doi: 10.1016/j.jmb.2023.168409. Epub 2023 , Dec 20. PMID:38128824<ref>PMID:38128824</ref>
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Description: Disulfide-stabilized HIV-1 CA hexamer in complex with PQBP1 Nt
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Pornillos, O]]
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<div class="pdbe-citations 8ty6" style="background-color:#fffaf0;"></div>
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[[Category: Piacentini, J]]
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== References ==
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[[Category: Ganser-Pornillos, B.K]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Large Structures]]
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[[Category: Ganser-Pornillos BK]]
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[[Category: Piacentini J]]
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[[Category: Pornillos O]]

Current revision

Disulfide-stabilized HIV-1 CA hexamer in complex with PQBP1 Nt

PDB ID 8ty6

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