1mhq

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[[Image:1mhq.jpg|left|200px]]
 
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==Crystal Structure Of Human GGA2 VHS Domain==
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The line below this paragraph, containing "STRUCTURE_1mhq", creates the "Structure Box" on the page.
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<StructureSection load='1mhq' size='340' side='right'caption='[[1mhq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mhq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MHQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhq OCA], [https://pdbe.org/1mhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mhq RCSB], [https://www.ebi.ac.uk/pdbsum/1mhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mhq ProSAT]</span></td></tr>
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{{STRUCTURE_1mhq| PDB=1mhq | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure Of Human GGA2 VHS Domain'''
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[https://www.uniprot.org/uniprot/GGA2_HUMAN GGA2_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Golgi-localized, gamma-ear-containing, ARF binding (GGA) proteins regulate intracellular vesicle transport by recognizing sorting signals on the cargo surface in the initial step of the budding process. The VHS (VPS27, Hrs, and STAM) domain of GGA binds with the signal peptides. Here, a crystal structure of the VHS domain of GGA2 is reported at 2.2 A resolution, which permits a direct comparison with that of homologous proteins, GGA1 and GGA3. Significant structural difference is present in the loop between helices 6 and 7, which forms part of the ligand binding pocket. Intrinsic fluorescence spectroscopic study indicates that this loop undergoes a conformational change upon ligand binding. Thus, the current structure suggests that a conformational change induced by ligand binding occurs in this part of the ligand pocket.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mhq_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1MHQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHQ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mhq ConSurf].
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Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket., Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC, FEBS Lett. 2003 Feb 27;537(1-3):171-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12606052 12606052]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Zhang, X C.]]
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[[Category: Zhang XC]]
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[[Category: Zhu, G.]]
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[[Category: Zhu G]]
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[[Category: Super helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:03:32 2008''
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Current revision

Crystal Structure Of Human GGA2 VHS Domain

PDB ID 1mhq

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