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1mq0

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Crystal Structure of Human Cytidine Deaminase

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Retrieved from "http://52.214.119.220/wiki/index.php/1mq0"

Categories: Homo sapiens | Large Structures | Chung SJ | Fromme JC | Verdine GL

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-[[Image:1mq0.gif|left|200px]]<br />
-<applet load="1mq0" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1mq0, resolution 2.40&Aring;" />
-'''Crystal Structure of Human Cytidine Deaminase'''<br />
-==Overview==
+==Crystal Structure of Human Cytidine Deaminase==
-Human cytidine deaminase (CDA) is an enzyme prominent for its role in, catalyzing metabolic processing of nucleoside-type anticancer and, antiviral agents. It is thus a promising target for the development of, small molecule therapeutic adjuvants. We report the first crystal, structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to, establish a canonical pi/pi-interaction with a key active site residue, Phe 137.
+<StructureSection load='1mq0' size='340' side='right'caption='[[1mq0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRD:1-BETA-RIBOFURANOSYL-1,3-DIAZEPINONE'>BRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq0 OCA], [https://pdbe.org/1mq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDD_HUMAN CDD_HUMAN] This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq0 ConSurf].
+<div style="clear:both"></div>
-==Disease==
+==See Also==
-Known disease associated with this structure: Anemia, congenital dyserythropoietic, type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607465 607465]]
+*[[Deaminase 3D structures|Deaminase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and BRD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA].
-==Reference==
-Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15689149 15689149]
-[[Category: Cytidine deaminase]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Chung, S.J.]]
+[[Category: Chung SJ]]
-[[Category: Fromme, J.C.]]
+[[Category: Fromme JC]]
-[[Category: Verdine, G.L.]]
+[[Category: Verdine GL]]
-[[Category: BRD]]
-[[Category: ZN]]
-[[Category: amine hydrolase]]
-[[Category: anticancer]]
-[[Category: chemotherapy]]
-[[Category: cytidine deaminase]]
-[[Category: diazepinone]]
-[[Category: drug]]
-[[Category: edge-to-face interaction]]
-[[Category: enzyme]]
-[[Category: human]]
-[[Category: inhibitor]]
-[[Category: leukemia]]
-[[Category: phi-phi interaction]]
-[[Category: protein]]
-[[Category: zinc]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:13:44 2007''

1mq0

From Proteopedia

Current revision

Crystal Structure of Human Cytidine Deaminase

Structural highlights

Function

Evolutionary Conservation

See Also

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