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8q1s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Pathogenic mutations of human phosphorylation sites affect protein-protein interactions== | |
| - | + | <StructureSection load='8q1s' size='340' side='right'caption='[[8q1s]], [[Resolution|resolution]] 3.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q1s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q1S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.23Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q1s OCA], [https://pdbe.org/8q1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q1s RCSB], [https://www.ebi.ac.uk/pdbsum/8q1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q1s ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Roske | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/1433E_HUMAN 1433E_HUMAN] Distal 17p13.3 microdeletion syndrome;17p13.3 microduplication syndrome;Miller-Dieker syndrome. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/1433E_HUMAN 1433E_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Daumke O]] | ||
| + | [[Category: Roske Y]] | ||
| + | [[Category: Rrustemi T]] | ||
| + | [[Category: Selbach M]] | ||
Current revision
Pathogenic mutations of human phosphorylation sites affect protein-protein interactions
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