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8tzr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Wnt3a bound to WLS and CALR== | |
| - | + | <StructureSection load='8tzr' size='340' side='right'caption='[[8tzr]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8tzr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TZR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tzr OCA], [https://pdbe.org/8tzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tzr RCSB], [https://www.ebi.ac.uk/pdbsum/8tzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tzr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/WNT3A_HUMAN WNT3A_HUMAN] Idiopathic juvenile osteoporosis. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/WNT3A_HUMAN WNT3A_HUMAN] Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).[UniProtKB:P27467]<ref>PMID:20093360</ref> <ref>PMID:21244856</ref> <ref>PMID:24841207</ref> <ref>PMID:26902720</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hu Q]] | ||
| + | [[Category: Li X]] | ||
| + | [[Category: Qi X]] | ||
Current revision
Structure of human Wnt3a bound to WLS and CALR
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Categories: Homo sapiens | Large Structures | Hu Q | Li X | Qi X
