1mn8

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[[Image:1mn8.gif|left|200px]]
 
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==Structure of Moloney Murine Leukaemia Virus Matrix Protein==
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The line below this paragraph, containing "STRUCTURE_1mn8", creates the "Structure Box" on the page.
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<StructureSection load='1mn8' size='340' side='right'caption='[[1mn8]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mn8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MN8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mn8 OCA], [https://pdbe.org/1mn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mn8 RCSB], [https://www.ebi.ac.uk/pdbsum/1mn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mn8 ProSAT]</span></td></tr>
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{{STRUCTURE_1mn8| PDB=1mn8 | SCENE= }}
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</table>
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== Function ==
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'''Structure of Moloney Murine Leukaemia Virus Matrix Protein'''
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[https://www.uniprot.org/uniprot/GAG_MLVMS GAG_MLVMS] Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release.<ref>PMID:19864377</ref> Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity).<ref>PMID:19864377</ref> Capsid protein p30 forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex (By similarity).<ref>PMID:19864377</ref> Nucleocapsid protein p10 is involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization.<ref>PMID:19864377</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/1mn8_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1MN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MN8 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mn8 ConSurf].
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Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins., Riffel N, Harlos K, Iourin O, Rao Z, Kingsman A, Stuart D, Fry E, Structure. 2002 Dec;10(12):1627-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12467570 12467570]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Moloney murine leukemia virus]]
[[Category: Moloney murine leukemia virus]]
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[[Category: Single protein]]
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[[Category: Fry E]]
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[[Category: Fry, E.]]
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[[Category: Harlos K]]
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[[Category: Harlos, K.]]
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[[Category: Iourin O]]
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[[Category: Iourin, O.]]
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[[Category: Kingsman A]]
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[[Category: Kingsman, A.]]
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[[Category: Rao Z]]
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[[Category: Rao, Z.]]
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[[Category: Riffel N]]
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[[Category: Riffel, N.]]
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[[Category: Stuart D]]
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[[Category: Stuart, D.]]
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[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:26:44 2008''
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Current revision

Structure of Moloney Murine Leukaemia Virus Matrix Protein

PDB ID 1mn8

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