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1mog

From Proteopedia

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[[Image:1mog.gif|left|200px]]
 
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==Crystal structure of H. salinarum dodecin==
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The line below this paragraph, containing "STRUCTURE_1mog", creates the "Structure Box" on the page.
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<StructureSection load='1mog' size='340' side='right'caption='[[1mog]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
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{{STRUCTURE_1mog| PDB=1mog | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mog OCA], [https://pdbe.org/1mog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mog RCSB], [https://www.ebi.ac.uk/pdbsum/1mog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mog ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of H. salinarum dodecin'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q9HPW4_HALSA Q9HPW4_HALSA]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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A novel, 68 amino acid long flavoprotein called dodecin has been discovered in the proteome of Halobacterium salinarum by inverse structural genomics. The 1.7 A crystal structure of this protein shows a dodecameric, hollow sphere-like arrangement of the protein subunits. Unlike other known flavoproteins, which bind only monomeric flavin cofactors, the structure of the dodecin oligomer comprises six riboflavin dimers. The dimerization of these riboflavins along the re-faces is mediated by aromatic, antiparallel pi staggering of their isoalloxazine moieties. A unique aromatic tetrade is formed by further sandwiching of the riboflavin dimers between the indole groups of two symmetry-related Trp36s. So far, the dodecins represent the smallest known flavoproteins. Based on the structure and the wide spread occurrences in pathogenic and soil eubacteria, a function in flavin storage or protection against radical or oxygenic stress is suggested for the dodecins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1mog_consurf.spt"</scriptWhenChecked>
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1MOG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOG OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum., Bieger B, Essen LO, Oesterhelt D, Structure. 2003 Apr;11(4):375-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679016 12679016]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mog ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Halobacterium salinarum]]
[[Category: Halobacterium salinarum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bieger, B.]]
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[[Category: Bieger B]]
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[[Category: Essen, L O.]]
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[[Category: Essen L-O]]
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[[Category: Oesterhelt, D.]]
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[[Category: Oesterhelt D]]
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[[Category: 23-symmetric dodecamer]]
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[[Category: Binding site for dimerized riboflavin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:31:17 2008''
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Current revision

Crystal structure of H. salinarum dodecin

PDB ID 1mog

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