1mp9

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[[Image:1mp9.gif|left|200px]]
 
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==TBP from a mesothermophilic archaeon, Sulfolobus acidocaldarius==
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The line below this paragraph, containing "STRUCTURE_1mp9", creates the "Structure Box" on the page.
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<StructureSection load='1mp9' size='340' side='right'caption='[[1mp9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MP9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mp9 OCA], [https://pdbe.org/1mp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mp9 ProSAT]</span></td></tr>
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{{STRUCTURE_1mp9| PDB=1mp9 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBP_SULAC TBP_SULAC] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/1mp9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mp9 ConSurf].
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<div style="clear:both"></div>
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'''TBP from a mesothermophilic archaeon, Sulfolobus acidocaldarius'''
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==See Also==
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*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of TATA binding protein (TBP) from a mesothermophilic archaeon, Sulfolobus acidocaldarius, has been determined at a resolution of 2.0 A with an R factor of 20.9%. By comparing this structure with the structures of TBPs from a hyperthermophilic archaeon and mesophilic eukaryotes, as well as by comparing amino acid sequences of TBPs from archaea, covering a wide range of optimum growth temperatures, two significant determinants of the stability of TBP have been identified: increasing the interior hydrophobicity by interaction between three residues, Val, Leu, and Ile, with further differentiation of the surface, and increasing its hydrophilicity and raising the cost of unfolding. These findings suggest directions along which the stability of TBP can be engineered.
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[[Category: Large Structures]]
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==About this Structure==
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1MP9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP9 OCA].
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==Reference==
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Origins of protein stability revealed by comparing crystal structures of TATA binding proteins., Koike H, Kawashima-Ohya Y, Yamasaki T, Clowney L, Katsuya Y, Suzuki M, Structure. 2004 Jan;12(1):157-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14725775 14725775]
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[[Category: Single protein]]
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[[Category: Sulfolobus acidocaldarius]]
[[Category: Sulfolobus acidocaldarius]]
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[[Category: Clowney, L.]]
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[[Category: Clowney L]]
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[[Category: Katsuya, Y.]]
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[[Category: Katsuya Y]]
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[[Category: Kawashima-Ohya, Y.]]
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[[Category: Kawashima-Ohya Y]]
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[[Category: Koike, H.]]
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[[Category: Koike H]]
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[[Category: Suzuki, M.]]
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[[Category: Suzuki M]]
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[[Category: Yamasaki, T.]]
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[[Category: Yamasaki T]]
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[[Category: Dna-binding protein]]
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[[Category: Transcription factor]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:33:06 2008''
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Current revision

TBP from a mesothermophilic archaeon, Sulfolobus acidocaldarius

PDB ID 1mp9

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