1mqt

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[[Image:1mqt.gif|left|200px]]
 
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==Swine Vesicular Disease Virus coat protein==
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The line below this paragraph, containing "STRUCTURE_1mqt", creates the "Structure Box" on the page.
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<StructureSection load='1mqt' size='340' side='right'caption='[[1mqt]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mqt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Swine_vesicular_disease_virus Swine vesicular disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
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{{STRUCTURE_1mqt| PDB=1mqt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqt OCA], [https://pdbe.org/1mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqt RCSB], [https://www.ebi.ac.uk/pdbsum/1mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8B8X4_9ENTO Q8B8X4_9ENTO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqt ConSurf].
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<div style="clear:both"></div>
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'''Swine Vesicular Disease Virus coat protein'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The structure of swine vesicular disease virus (SVDV) was solved and refined at a 3.0-A resolution by X-ray crystallography to gain information about the role of sequence changes that occurred as this virus evolved from the parental human pathogen coxsackievirus B5 (CVB5). These amino acid substitutions can be clustered in five distinct regions: (i) the antigenic sites, (ii) the hydrophobic pocket of the VP1 beta-sandwich, (iii) the putative CAR binding site, (iv) the putative heparan sulfate binding site, and (v) the fivefold axis. The VP1 pocket is occupied by a branched pocket factor, apparently different from that present in the closely related virus CVB3 and in other picornaviruses. This finding may be relevant for the design of new antiviral compounds against this site. Density consistent with the presence of ions was observed on the fivefold and threefold axes. The structure also provided an accurate description of the putative receptor binding sites.
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[[Category: Large Structures]]
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==About this Structure==
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1MQT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Swine_vesicular_disease_virus Swine vesicular disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQT OCA].
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==Reference==
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Structure of swine vesicular disease virus: mapping of changes occurring during adaptation of human coxsackie B5 virus to infect swine., Verdaguer N, Jimenez-Clavero MA, Fita I, Ley V, J Virol. 2003 Sep;77(18):9780-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12941886 12941886]
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[[Category: Protein complex]]
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[[Category: Swine vesicular disease virus]]
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[[Category: Fita, I.]]
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[[Category: Jimenez-Clavero, M A.]]
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[[Category: Ley, V.]]
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[[Category: Verdaguer, N.]]
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[[Category: Enterovirus]]
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[[Category: Icosahedral virus]]
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[[Category: Svdv coat protein]]
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[[Category: Swine vesicular disease virus]]
[[Category: Swine vesicular disease virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:36:38 2008''
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[[Category: Fita I]]
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[[Category: Jimenez-Clavero MA]]
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[[Category: Ley V]]
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[[Category: Verdaguer N]]

Current revision

Swine Vesicular Disease Virus coat protein

PDB ID 1mqt

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