1mrp

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[[Image:1mrp.jpg|left|200px]]
 
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==FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE==
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The line below this paragraph, containing "STRUCTURE_1mrp", creates the "Structure Box" on the page.
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<StructureSection load='1mrp' size='340' side='right'caption='[[1mrp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MRP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1mrp| PDB=1mrp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrp OCA], [https://pdbe.org/1mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mrp RCSB], [https://www.ebi.ac.uk/pdbsum/1mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FBPA_HAEIN FBPA_HAEIN] Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mrp ConSurf].
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<div style="clear:both"></div>
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'''FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE'''
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==See Also==
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*[[Ferric-binding protein|Ferric-binding protein]]
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__TOC__
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==Overview==
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</StructureSection>
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The first crystal structure of the iron-transporter ferric ion-binding protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals the structural basis for iron uptake and transport required by several important bacterial pathogens. Paradoxically, although hFBP belongs to a protein superfamily which includes human transferrin, iron binding in hFBP and transferrin appears to have developed independently by convergent evolution. Structural comparison of hFBP with other prokaryotic periplasmic transport proteins and the eukaryotic transferrins suggests that these proteins are related by divergent evolution from an anion-binding common ancestor, not from an iron-binding ancestor. The iron binding site of hFBP incorporates a water and an exogenous phosphate ion as iron ligands and exhibits nearly ideal octahedral metal coordination. FBP is highly conserved, required for virulence, and is a nodal point for free iron uptake in several Gram-negative pathogenic bacteria, thus providing a potential target for broad-spectrum antibacterial drug design against human pathogens such as H. influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis.
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==About this Structure==
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1MRP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA].
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==Reference==
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Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily., Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE, Nat Struct Biol. 1997 Nov;4(11):919-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360608 9360608]
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arvai, A S.]]
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[[Category: Arvai AS]]
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[[Category: Bruns, C M.]]
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[[Category: Bruns CM]]
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[[Category: Mcree, D E.]]
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[[Category: Mcree DE]]
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[[Category: Mctigue, M A.]]
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[[Category: Mctigue MA]]
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[[Category: Mietzner, T A.]]
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[[Category: Mietzner TA]]
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[[Category: Nowalk, A J.]]
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[[Category: Nowalk AJ]]
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[[Category: Vaughan, K G.]]
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[[Category: Vaughan KG]]
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[[Category: Ferric iron binding protein]]
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[[Category: Iron transport]]
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[[Category: Periplasmic binding protein]]
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[[Category: Transferrin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:38:29 2008''
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Current revision

FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE

PDB ID 1mrp

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