1n26

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(New page: 200px<br /> <applet load="1n26" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n26, resolution 2.4&Aring;" /> '''Crystal Structure of...)
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[[Image:1n26.gif|left|200px]]<br />
 
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<applet load="1n26" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n26, resolution 2.4&Aring;" />
 
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'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''<br />
 
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==Overview==
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==Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain==
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Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in, the pathogenesis of multiple myeloma, autoimmune diseases and prostate, cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and, the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A), of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain, (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the, cytokine-binding domain, are structurally similar to known, cytokine-binding domains. The head-to-tail packing of two closely, associated IL-6R molecules observed in the crystal may be representative, of the configuration of the physiological dimer of IL-6R and provides new, insight into the architecture of the IL-6R complex.
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<StructureSection load='1n26' size='340' side='right'caption='[[1n26]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N26 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n26 OCA], [https://pdbe.org/1n26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n26 RCSB], [https://www.ebi.ac.uk/pdbsum/1n26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n26 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/1n26_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n26 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.
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==About this Structure==
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Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.,Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182<ref>PMID:12461182</ref>
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1N26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, SO4 and CYS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12461182 12461182]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1n26" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Branson, K.M.]]
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[[Category: Donkelaar, A.van.]]
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[[Category: Hall, N.E.]]
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[[Category: Ivancic, N.]]
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[[Category: Ji, H.]]
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[[Category: Lou, M.Z.]]
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[[Category: Moritz, R.L.]]
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[[Category: Simpson, R.J.]]
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[[Category: Varghese, J.N.]]
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[[Category: CYS]]
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[[Category: NAG]]
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[[Category: SO4]]
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[[Category: glycoprotein]]
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[[Category: immunoglobulin domain]]
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[[Category: transmembrane]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:16:57 2007''
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==See Also==
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Branson KM]]
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[[Category: Hall NE]]
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[[Category: Ivancic N]]
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[[Category: Ji H]]
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[[Category: Lou M-Z]]
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[[Category: Moritz RL]]
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[[Category: Simpson RJ]]
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[[Category: Varghese JN]]
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[[Category: Van Donkelaar A]]

Current revision

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

PDB ID 1n26

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