1msi

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[[Image:1msi.gif|left|200px]]
 
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==STRUCTURE OF ANTIFREEZE GLYCOPROTEIN QAE(HPLC 12)==
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The line below this paragraph, containing "STRUCTURE_1msi", creates the "Structure Box" on the page.
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<StructureSection load='1msi' size='340' side='right'caption='[[1msi]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1msi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zoarces_americanus Zoarces americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MSI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1msi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1msi OCA], [https://pdbe.org/1msi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1msi RCSB], [https://www.ebi.ac.uk/pdbsum/1msi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1msi ProSAT]</span></td></tr>
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{{STRUCTURE_1msi| PDB=1msi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANP12_ZOAAM ANP12_ZOAAM] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1msi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1msi ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF ANTIFREEZE GLYCOPROTEIN QAE(HPLC 12)'''
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==See Also==
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*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Antifreeze proteins (AFPs) have the unique ability to adsorb to ice and inhibit its growth. Many organisms ranging from fish to bacteria use AFPs to retard freezing or lessen the damage incurred upon freezing and thawing. The ice-binding mechanism of the long linear alpha-helical type I AFPs has been attributed to their regularly spaced polar residues matching the ice lattice along a pyramidal plane. In contrast, it is not known how globular antifreeze proteins such as type III AFP that lack repeating ice-binding residues bind to ice. Here we report the 1.25 A crystal structure of recombinant type III AFP (QAE isoform) from eel pout (Macrozoarces americanus), which reveals a remarkably flat amphipathic ice-binding site where five hydrogen-bonding atoms match two ranks of oxygens on the [1010] ice prism plane in the &lt;0001&gt; direction, giving high ice-binding affinity and specificity. This binding site, substantiated by the structures and properties of several ice-binding site mutants, suggests that the AFP occupies a niche in the ice surface in which it covers the basal plane while binding to the prism face.
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[[Category: Large Structures]]
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[[Category: Zoarces americanus]]
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==About this Structure==
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[[Category: Chao H]]
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1MSI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macrozoarces_americanus Macrozoarces americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSI OCA].
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[[Category: Davies PL]]
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[[Category: Deluca CI]]
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==Reference==
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[[Category: Jia Z]]
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Structural basis for the binding of a globular antifreeze protein to ice., Jia Z, DeLuca CI, Chao H, Davies PL, Nature. 1996 Nov 21;384(6606):285-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8918883 8918883]
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[[Category: Macrozoarces americanus]]
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[[Category: Single protein]]
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[[Category: Chao, H.]]
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[[Category: Davies, P L.]]
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[[Category: Deluca, C I.]]
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[[Category: Jia, Z.]]
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[[Category: Antifreeze protein]]
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[[Category: Multigene family]]
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[[Category: Thermal hysteresis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:40:26 2008''
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Current revision

STRUCTURE OF ANTIFREEZE GLYCOPROTEIN QAE(HPLC 12)

PDB ID 1msi

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