8q3j

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'''Unreleased structure'''
 
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The entry 8q3j is ON HOLD until Paper Publication
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==Crystal structure of mIL-38 in complex with a neutralizing Fab e04 fragment==
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<StructureSection load='8q3j' size='340' side='right'caption='[[8q3j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Garcia-Pardo, J., Da Silva, P., Mora, J., Wiechmann, S., Putyrski, M., You, X., Kannt, A., Ernst, A., Brune, B., Weigert, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8q3j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q3J FirstGlance]. <br>
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Description: Crystal structure of mIL-38 in complex with a neutralizing Fab e04 fragment
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q3j OCA], [https://pdbe.org/8q3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q3j RCSB], [https://www.ebi.ac.uk/pdbsum/8q3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q3j ProSAT]</span></td></tr>
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[[Category: Putyrski, M]]
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</table>
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[[Category: Mora, J]]
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== Function ==
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[[Category: Garcia-Pardo, J]]
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[https://www.uniprot.org/uniprot/IL1FA_MOUSE IL1FA_MOUSE] Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity).
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[[Category: Wiechmann, S]]
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__TOC__
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[[Category: Da Silva, P]]
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</StructureSection>
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[[Category: You, X]]
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[[Category: Large Structures]]
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[[Category: Weigert, A]]
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[[Category: Mus musculus]]
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[[Category: Ernst, A]]
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[[Category: Brune B]]
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[[Category: Kannt, A]]
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[[Category: Da Silva P]]
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[[Category: Brune, B]]
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[[Category: Ernst A]]
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[[Category: Garcia-Pardo J]]
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[[Category: Kannt A]]
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[[Category: Mora J]]
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[[Category: Putyrski M]]
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[[Category: Weigert A]]
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[[Category: Wiechmann S]]
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[[Category: You X]]

Current revision

Crystal structure of mIL-38 in complex with a neutralizing Fab e04 fragment

PDB ID 8q3j

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