8qhh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of the green kiwi fruit allergen Act d 8.0101== | |
| + | <StructureSection load='8qhh' size='340' side='right'caption='[[8qhh]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8qhh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinidia_deliciosa Actinidia deliciosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QHH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qhh OCA], [https://pdbe.org/8qhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qhh RCSB], [https://www.ebi.ac.uk/pdbsum/8qhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qhh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/D1YSM5_ACTDE D1YSM5_ACTDE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Kiwifruits have become one of the most common food sources triggering allergic reactions. In patients suffering from birch pollen related food allergy, reactions result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1, followed by immunological cross-reactivity to structurally homologous proteins in kiwifruit. Clinical symptoms range from scratching and itching of the oral cavity to more severe immunological reactions such as rhino conjunctivitis. In this work we assigned backbone and side chain (1)H, (13)C and (15)N chemical shifts of the 17 kDa PR-10 allergens Act c 8.0101 and Act d 8.0101 from golden (Actinidia chinesis) and green (Actinidia deliciosa) kiwifruit by solution NMR spectroscopy. The chemical shift data confirm the characteristic Bet v 1 fold for both proteins, consisting of a seven-stranded antiparallel beta-sheet interrupted by two short alpha-helices, along with a long C-terminal alpha-helix. Our data provide the basis for determining the three-dimensional solution structures of these proteins and characterizing their immunological cross-reactivity on a structural basis. | ||
| - | + | NMR resonance assignments of the PR-10 allergens Act c 8 and Act d 8 from golden and green kiwifruit.,Zeindl R, Tollinger M Biomol NMR Assign. 2021 Oct;15(2):367-371. doi: 10.1007/s12104-021-10031-w. Epub , 2021 Jun 9. PMID:34106433<ref>PMID:34106433</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8qhh" style="background-color:#fffaf0;"></div> |
| - | [[Category: Tollinger | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Actinidia deliciosa]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tollinger M]] | ||
| + | [[Category: Zeindl R]] | ||
Current revision
NMR solution structure of the green kiwi fruit allergen Act d 8.0101
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