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| - | [[Image:1myu.gif|left|200px]] | |
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| - | <!--
| + | ==Lipid induced conformation of the tachykinin peptide Kassinin== |
| - | The line below this paragraph, containing "STRUCTURE_1myu", creates the "Structure Box" on the page.
| + | <StructureSection load='1myu' size='340' side='right'caption='[[1myu]]' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[1myu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kassina_senegalensis Kassina senegalensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYU FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | -->
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myu OCA], [https://pdbe.org/1myu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myu RCSB], [https://www.ebi.ac.uk/pdbsum/1myu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myu ProSAT]</span></td></tr> |
| - | {{STRUCTURE_1myu| PDB=1myu | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | '''Lipid induced conformation of the tachykinin peptide Kassinin'''
| + | [https://www.uniprot.org/uniprot/TKN_KASSE TKN_KASSE] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. |
| - | | + | __TOC__ |
| - | | + | </StructureSection> |
| - | ==Overview== | + | [[Category: Kassina senegalensis]] |
| - | Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide of amphibian origin, has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy and distance geometry calculations. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water Kassinin prefers to be in an extended chain conformation, in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M12) of the peptide. N-terminus though less defined also displays some degree of order and a possible turn structure. The conformation adopted by Kassinin in the presence of DPC micelles is consistent with the structural motif typical of neurokinin-1 selective agonists and with that reported for Eledoisin in hydrophobic environment.
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Cowsik SM]] |
| - | ==About this Structure== | + | [[Category: Grace RC]] |
| - | 1MYU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA].
| + | [[Category: Lynn AM]] |
| - | | + | |
| - | ==Reference== | + | |
| - | Lipid induced conformation of the tachykinin peptide Kassinin., Grace RC, Lynn AM, Cowsik SM, J Biomol Struct Dyn. 2001 Feb;18(4):611-21, 623-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11245256 11245256]
| + | |
| - | [[Category: Single protein]] | + | |
| - | [[Category: Cowsik, S M.]] | + | |
| - | [[Category: Grace, R C.]] | + | |
| - | [[Category: Lynn, A M.]] | + | |
| - | [[Category: 3-10 helix]] | + | |
| - | [[Category: Dpc micelle]] | + | |
| - | [[Category: Helical core]] | + | |
| - | [[Category: Lipid induced conformation]] | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:52:49 2008''
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