1n2d

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[[Image:1n2d.gif|left|200px]]
 
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==Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin==
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The line below this paragraph, containing "STRUCTURE_1n2d", creates the "Structure Box" on the page.
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<StructureSection load='1n2d' size='340' side='right'caption='[[1n2d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n2d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N2D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n2d OCA], [https://pdbe.org/1n2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n2d RCSB], [https://www.ebi.ac.uk/pdbsum/1n2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n2d ProSAT]</span></td></tr>
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{{STRUCTURE_1n2d| PDB=1n2d | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/1n2d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n2d ConSurf].
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<div style="clear:both"></div>
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'''Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin'''
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Overview==
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<references/>
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Mlc1p is a calmodulin-like protein from the budding yeast Saccharomyces cerevisiae, where it has been identified as a subunit of a class V myosin, Myo2p, and a binding partner of an IQGAP-like protein, Iqg1p. Through its interactions with these two proteins, Mlc1p plays a role in polarized growth and cytokinesis. Mlc1p has been crystallized in complexes with four different IQ target motifs from the neck region of Myo2p: IQ2, IQ3, IQ4 and IQ2-IQ3 (referred to as IQ2,3). Electron-density maps for two of the complexes (Mlc1p-IQ4 and Mlc1p-IQ2,3) were obtained from multiple anomalous dispersion (MAD) experiments based on selenomethionine derivatives. The other two structures (Mlc1p-IQ2 and Mlc1p-IQ3) were determined by molecular replacement using the partially refined structure of Mlc1p-IQ2,3 as a search model.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1N2D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N2D OCA].
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==Reference==
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Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V., Terrak M, Otterbein LR, Wu G, Palecanda LA, Lu RC, Dominguez R, Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1882-5. Epub, 2002 Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12351846 12351846]
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[[Category: Protein complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Dominguez, R.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Lu, R C.]]
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[[Category: Dominguez R]]
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[[Category: Stafford, W F.]]
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[[Category: Lu RC]]
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[[Category: Terrak, M.]]
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[[Category: Stafford WF]]
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[[Category: Wu, G.]]
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[[Category: Terrak M]]
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[[Category: Iq motif]]
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[[Category: Wu G]]
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[[Category: Myosin light chain]]
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[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:00:16 2008''
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Current revision

Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin

PDB ID 1n2d

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