1n3n

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[[Image:1n3n.gif|left|200px]]
 
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==Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db==
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The line below this paragraph, containing "STRUCTURE_1n3n", creates the "Structure Box" on the page.
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<StructureSection load='1n3n' size='340' side='right'caption='[[1n3n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1n3n| PDB=1n3n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3n OCA], [https://pdbe.org/1n3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3n RCSB], [https://www.ebi.ac.uk/pdbsum/1n3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n3n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.
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'''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db'''
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Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db.,Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896<ref>PMID:12753896</ref>
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==Overview==
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The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1N3N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA].
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</div>
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<div class="pdbe-citations 1n3n" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12753896 12753896]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Capitani G]]
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[[Category: Capitani, G.]]
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[[Category: Ciatto C]]
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[[Category: Ciatto, C.]]
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[[Category: Grutter MG]]
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[[Category: Grutter, M G.]]
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[[Category: Pecorari F]]
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[[Category: Pecorari, F.]]
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[[Category: Pluckthun A]]
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[[Category: Pluckthun, A.]]
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[[Category: Tissot AC]]
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[[Category: Tissot, A C.]]
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[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:02:50 2008''
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Current revision

Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db

PDB ID 1n3n

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