2fqn
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fqn OCA], [https://pdbe.org/2fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fqn RCSB], [https://www.ebi.ac.uk/pdbsum/2fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fqn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fqn OCA], [https://pdbe.org/2fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fqn RCSB], [https://www.ebi.ac.uk/pdbsum/2fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fqn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493. | ||
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| - | Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.,Kondo J, Urzhumtsev A, Westhof E Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297<ref>PMID:16452297</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2fqn" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site
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