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8qmz
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8qmz is ON HOLD Authors: Kumar, A., Zhu, F., Ehrler, J.M.H., Li, F., Empel, C., Xu, Y., Atodiresei, I., Koenigs, R.M., Proschak, E., Knapp, S., Stru...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Soluble epoxide hydrolase in complex with RK4== | |
| - | + | <StructureSection load='8qmz' size='340' side='right'caption='[[8qmz]], [[Resolution|resolution]] 1.47Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qmz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W6O:(3~{a}~{R},6~{a}~{S})-~{N}-[(2,4-dichlorophenyl)methyl]-2-(4-methylphenyl)sulfonyl-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-5-carboxamide'>W6O</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmz OCA], [https://pdbe.org/8qmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmz RCSB], [https://www.ebi.ac.uk/pdbsum/8qmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmz ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Atodiresei I]] |
| + | [[Category: Ehrler JMH]] | ||
| + | [[Category: Empel C]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Koenigs RM]] | ||
| + | [[Category: Kumar A]] | ||
| + | [[Category: Li F]] | ||
| + | [[Category: Proschak E]] | ||
| + | [[Category: Xu Y]] | ||
| + | [[Category: Zhu F]] | ||
Current revision
Soluble epoxide hydrolase in complex with RK4
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Categories: Homo sapiens | Large Structures | Atodiresei I | Ehrler JMH | Empel C | Knapp S | Koenigs RM | Kumar A | Li F | Proschak E | Xu Y | Zhu F
