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8w4v
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human HSP90 in complex with compound 4== | |
| - | + | <StructureSection load='8w4v' size='340' side='right'caption='[[8w4v]], [[Resolution|resolution]] 1.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8w4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W4V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Q9O:4-[2-[(dimethylamino)methyl]phenyl]sulfanylbenzene-1,3-diol'>Q9O</scene></td></tr> |
| - | [[Category: Bai | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w4v OCA], [https://pdbe.org/8w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w4v RCSB], [https://www.ebi.ac.uk/pdbsum/8w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w4v ProSAT]</span></td></tr> |
| - | [[Category: Xu | + | </table> |
| - | [[Category: Zhang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bai F]] | ||
| + | [[Category: Xu C]] | ||
| + | [[Category: Zhang XL]] | ||
Current revision
Crystal structure of human HSP90 in complex with compound 4
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Categories: Homo sapiens | Large Structures | Bai F | Xu C | Zhang XL
