8w6c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of NaDC1 with Citrate== | |
| - | + | <StructureSection load='8w6c' size='340' side='right'caption='[[8w6c]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8w6c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W6C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PH:1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE'>3PH</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w6c OCA], [https://pdbe.org/8w6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w6c RCSB], [https://www.ebi.ac.uk/pdbsum/8w6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w6c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S13A2_HUMAN S13A2_HUMAN] Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity).[UniProtKB:Q9ES88]<ref>PMID:10894787</ref> <ref>PMID:8967342</ref> <ref>PMID:9668069</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Chi X]] | ||
| + | [[Category: Dai L]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Shen Y]] | ||
| + | [[Category: Shi T]] | ||
| + | [[Category: Wang Z]] | ||
| + | [[Category: Yan R]] | ||
| + | [[Category: Yang H]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
CryoEM structure of NaDC1 with Citrate
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Categories: Homo sapiens | Large Structures | Chen Y | Chi X | Dai L | Li Y | Shen Y | Shi T | Wang Z | Yan R | Yang H | Zhang Y
