1n66

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[[Image:1n66.gif|left|200px]]
 
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==Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR==
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The line below this paragraph, containing "STRUCTURE_1n66", creates the "Structure Box" on the page.
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<StructureSection load='1n66' size='340' side='right'caption='[[1n66]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n66]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N66 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n66 OCA], [https://pdbe.org/1n66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n66 RCSB], [https://www.ebi.ac.uk/pdbsum/1n66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n66 ProSAT]</span></td></tr>
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{{STRUCTURE_1n66| PDB=1n66 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR'''
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== Publication Abstract from PubMed ==
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==Overview==
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Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
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==About this Structure==
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Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs.,Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:12909008<ref>PMID:12909008</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs., Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA, J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12909008 12909008]
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</div>
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[[Category: Heus, H A.]]
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<div class="pdbe-citations 1n66" style="background-color:#fffaf0;"></div>
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[[Category: Hilbers, C W.]]
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== References ==
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[[Category: Kuppeveld, F J.van.]]
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<references/>
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[[Category: Lescrinier, E M.]]
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__TOC__
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[[Category: Melchers, W J.]]
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</StructureSection>
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[[Category: Tessari, M.]]
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[[Category: Large Structures]]
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[[Category: Rna internal loop]]
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[[Category: Heus HA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:08:40 2008''
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[[Category: Hilbers CW]]
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[[Category: Lescrinier EM]]
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[[Category: Melchers WJ]]
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[[Category: Tessari M]]
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[[Category: Van Kuppeveld FJ]]

Current revision

Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR

PDB ID 1n66

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