Osimertinib
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| - | <StructureSection load='' size='340' side='right' caption=' | + | <StructureSection load='' size='340' side='right' caption='Osimertinib' scene='99/999451/Cv/1'> |
Osimertinib, sold under the brand name Tagrisso,<ref name="a4">[https://www.who.int/medicines/publications/druginformation/INN_List113.pdf "Proposed INN: List 113"] (PDF). International Nonproprietary Names for Pharmaceutical Substances (INN). 29 (2): 285. 2015. Archived (PDF) from the original on 28 April 2017. Retrieved 16 November 2015</ref> is a medication used to treat non-small-cell lung carcinomas with specific mutations.<ref name="a5">PMID:26169963</ref><ref name="a6">PMID:26370354</ref> It is a third-generation [[epidermal growth factor receptor]] tyrosine kinase inhibitor (see [[Receptor tyrosine kinases]]). See also [https://en.wikipedia.org/wiki/Osimertinib Osimertinib]. | Osimertinib, sold under the brand name Tagrisso,<ref name="a4">[https://www.who.int/medicines/publications/druginformation/INN_List113.pdf "Proposed INN: List 113"] (PDF). International Nonproprietary Names for Pharmaceutical Substances (INN). 29 (2): 285. 2015. Archived (PDF) from the original on 28 April 2017. Retrieved 16 November 2015</ref> is a medication used to treat non-small-cell lung carcinomas with specific mutations.<ref name="a5">PMID:26169963</ref><ref name="a6">PMID:26370354</ref> It is a third-generation [[epidermal growth factor receptor]] tyrosine kinase inhibitor (see [[Receptor tyrosine kinases]]). See also [https://en.wikipedia.org/wiki/Osimertinib Osimertinib]. | ||
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| + | Osimertinib preferentially binds irreversibly to mutated epidermal growth factor receptor proteins, particularly those with more common mutations in lung cancer such as L858R mutation or an exon 19 deletion.<ref name="a2">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e81b4a7-b971-45e1-9c31-29cea8c87ce7 "Tagrisso- osimertinib tablet, film coated"]. DailyMed. 5 June 2020. Retrieved 16 October 2020.</ref> | ||
<scene name='99/999451/Overall/1'>Crystal Structure of EGFR(L858R/T790M/C797S) in complex with Osimertinib</scene> ([[6lud]]). | <scene name='99/999451/Overall/1'>Crystal Structure of EGFR(L858R/T790M/C797S) in complex with Osimertinib</scene> ([[6lud]]). | ||
Current revision
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References
- ↑ "Proposed INN: List 113" (PDF). International Nonproprietary Names for Pharmaceutical Substances (INN). 29 (2): 285. 2015. Archived (PDF) from the original on 28 April 2017. Retrieved 16 November 2015
- ↑ Ayeni D, Politi K, Goldberg SB. Emerging Agents and New Mutations in EGFR-Mutant Lung Cancer. Clin Cancer Res. 2015 Sep 1;21(17):3818-20. PMID:26169963 doi:10.1158/1078-0432.CCR-15-1211
- ↑ Tan CS, Gilligan D, Pacey S. Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. Lancet Oncol. 2015 Sep;16(9):e447-e459. PMID:26370354 doi:10.1016/S1470-2045(15)00246-6
- ↑ "Tagrisso- osimertinib tablet, film coated". DailyMed. 5 June 2020. Retrieved 16 October 2020.
