7yq8

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'''Unreleased structure'''
 
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The entry 7yq8 is ON HOLD until 2025-02-05
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==Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide==
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<StructureSection load='7yq8' size='340' side='right'caption='[[7yq8]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yq8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YQ8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yq8 OCA], [https://pdbe.org/7yq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yq8 RCSB], [https://www.ebi.ac.uk/pdbsum/7yq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bu H]]
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[[Category: Bunch H]]
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[[Category: Cong A]]
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[[Category: Ehara H]]
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[[Category: Jang J]]
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[[Category: Jeong J]]
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[[Category: Kim D]]
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[[Category: Naganuma M]]
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[[Category: Nakagawa R]]
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[[Category: Schellenberg MJ]]
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[[Category: Sekine S]]

Current revision

Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide

PDB ID 7yq8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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