8wlz
From Proteopedia
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(New page: '''Unreleased structure''' The entry 8wlz is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the WIV1 S-hACE2 complex== | |
| - | + | <StructureSection load='8wlz' size='340' side='right'caption='[[8wlz]], [[Resolution|resolution]] 4.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8wlz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_SARS-like_coronavirus_WIV1 Bat SARS-like coronavirus WIV1], [https://en.wikipedia.org/wiki/Enterobacteria_phage_T6 Enterobacteria phage T6] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WLZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.45Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wlz OCA], [https://pdbe.org/8wlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wlz RCSB], [https://www.ebi.ac.uk/pdbsum/8wlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wlz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A346FJN8_BPT6 A0A346FJN8_BPT6] [https://www.uniprot.org/uniprot/U5WI05_SARS U5WI05_SARS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bat SARS-like coronavirus WIV1]] | ||
| + | [[Category: Enterobacteria phage T6]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Qiao S]] | ||
| + | [[Category: Wang X]] | ||
Current revision
Cryo-EM structure of the WIV1 S-hACE2 complex
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