1ndk

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[[Image:1ndk.jpg|left|200px]]
 
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==X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE==
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The line below this paragraph, containing "STRUCTURE_1ndk", creates the "Structure Box" on the page.
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<StructureSection load='1ndk' size='340' side='right'caption='[[1ndk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ndk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ndk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndk OCA], [https://pdbe.org/1ndk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ndk RCSB], [https://www.ebi.ac.uk/pdbsum/1ndk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ndk ProSAT]</span></td></tr>
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{{STRUCTURE_1ndk| PDB=1ndk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NDKC_DICDI NDKC_DICDI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1ndk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ndk ConSurf].
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<div style="clear:both"></div>
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'''X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE'''
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==See Also==
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*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The X-ray structure of a point mutant of nucleoside diphosphate kinase (NDP kinase) from Dictyostelium discoideum has been determined to 2.2 A resolution. The enzyme is a hexamer made of identical subunits with a novel mononucleotide binding fold. Each subunit contains an alpha/beta domain with a four stranded, antiparallel beta-sheet. The topology is different from adenylate kinase, but identical to the allosteric domain of Escherichia coli ATCase regulatory subunits, which bind mononucleotides at an equivalent position. Dimer contacts between NDP kinase subunits within the hexamer are similar to those in ATCase. Trimer contacts involve a large loop of polypeptide chain that bears the site of the Pro----Ser substitution in Killer of prune (K-pn) mutants of the highly homologous Drosophila enzyme. Properties of Drosophila NDP kinase, the product of the awd developmental gene, and of the human enzyme, the product of the nm23 genes in tumorigenesis, are discussed in view of the three-dimensional structure and of possible interactions of NDP kinase with other nucleotide binding proteins.
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==About this Structure==
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1NDK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDK OCA].
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==Reference==
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X-ray structure of nucleoside diphosphate kinase., Dumas C, Lascu I, Morera S, Glaser P, Fourme R, Wallet V, Lacombe ML, Veron M, Janin J, EMBO J. 1992 Sep;11(9):3203-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1324167 1324167]
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[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Nucleoside-diphosphate kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Dumas C]]
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[[Category: Dumas, C.]]
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[[Category: Janin J]]
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[[Category: Janin, J.]]
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[[Category: Lascu I]]
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[[Category: Lascu, I.]]
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[[Category: Morera S]]
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[[Category: Morera, S.]]
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[[Category: Veron M]]
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[[Category: Veron, M.]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:24:24 2008''
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Current revision

X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE

PDB ID 1ndk

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