1ngt

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[[Image:1ngt.gif|left|200px]]
 
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==The Role of Minor Groove Functional Groups in DNA Hydration==
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The line below this paragraph, containing "STRUCTURE_1ngt", creates the "Structure Box" on the page.
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<StructureSection load='1ngt' size='340' side='right'caption='[[1ngt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene></td></tr>
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{{STRUCTURE_1ngt| PDB=1ngt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [https://pdbe.org/1ngt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB], [https://www.ebi.ac.uk/pdbsum/1ngt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngt ProSAT]</span></td></tr>
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</table>
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'''The Role of Minor Groove Functional Groups in DNA Hydration'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Lan T]]
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Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.
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[[Category: McLaughlin LW]]
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[[Category: Williams LD]]
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==About this Structure==
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[[Category: Woods KK]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].
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==Reference==
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The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595562 12595562]
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[[Category: Lan, T.]]
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[[Category: McLaughlin, L W.]]
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[[Category: Williams, L D.]]
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[[Category: Woods, K K.]]
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[[Category: Dna conformation]]
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[[Category: Modified base]]
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[[Category: Spine of hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:30:52 2008''
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Current revision

The Role of Minor Groove Functional Groups in DNA Hydration

PDB ID 1ngt

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