8qs0
From Proteopedia
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(New page: '''Unreleased structure''' The entry 8qs0 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Acyl-ACP thioesterase from Lemna paucicostata in complex with a spirolactam== | |
| + | <StructureSection load='8qs0' size='340' side='right'caption='[[8qs0]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8qs0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lemna_aequinoctialis Lemna aequinoctialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QS0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WOX:(5~{S})-9-[[2,6-bis(fluoranyl)phenyl]methyl]-3-(3-methylthiophen-2-yl)-1-oxa-2,9-diazaspiro[4.5]dec-2-en-10-one'>WOX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qs0 OCA], [https://pdbe.org/8qs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qs0 RCSB], [https://www.ebi.ac.uk/pdbsum/8qs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qs0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | BACKGROUND: There are various methods to control weeds, that represent considerable challenges for farmers around the globe, although applying small molecular compounds is still the most effective and versatile technology to date. In the search for novel chemical entities with new modes-of-action that can control weeds displaying resistance, we have investigated two spirocyclic classes of acyl-ACP thioesterase inhibitors based on X-ray co-crystal structures and subsequent modelling studies. RESULTS: By exploiting scaffold-hopping and isostere concepts, we were able to identify new spirolactam-based lead structures showing promising activity in vivo against commercially important grass weeds in line with strong target affinity. CONCLUSION: The present work covers a series of novel herbicidal lead structures that contain a spirocyclic lactam as a structural key feature carrying ortho-substituted benzyl or heteroarylmethylene side chains. These new compounds show good acyl-ACP thioesterase inhibition in line with strong herbicidal activity. Glasshouse trials showed that the spirolactams outlined herein display promising control of grass-weed species in pre-emergence application combined with dose-response windows that enable partial selectivity in wheat and corn. Remarkably, some of the novel acyl-ACP thioesterase-inhibitors showed efficacy against resistant grass weeds such as Alopecurus myosuroides and Lolium spp. on competitive levels compared with commercial standards. (c) 2024 Society of Chemical Industry. | ||
| - | + | Discovery and optimization of spirocyclic lactams that inhibit acyl-ACP thioesterase.,Asmus E, Barber DM, Bojack G, Bollenbach-Wahl B, Brown RW, Doller U, Freigang J, Gatzweiler E, Getachew R, Heinemann I, Hohmann S, Ko KY, Laber B, Lange G, Mattison RL, Minn K, Muller T, Petry T, Reingruber AM, Schmutzler D, Svejda A, Frackenpohl J Pest Manag Sci. 2025 May;81(5):2598-2616. doi: 10.1002/ps.8015. Epub 2024 Feb 26. PMID:38334233<ref>PMID:38334233</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8qs0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lemna aequinoctialis]] | ||
| + | [[Category: Freigang J]] | ||
Current revision
Acyl-ACP thioesterase from Lemna paucicostata in complex with a spirolactam
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