8pxs

From Proteopedia

(Difference between revisions)

Current revision

Short RNA binding to peptide amyloids

Structural highlights

8pxs is a 11 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solid-state NMR, 10 models
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Interactions between RNA and proteins are the cornerstone of many important biological processes from transcription and translation to gene regulation, yet little is known about the ancient origin of said interactions. We hypothesized that peptide amyloids played a role in the origin of life and that their repetitive structure lends itself to building interfaces with other polymers through avidity. Here, we report that short RNA with a minimum length of three nucleotides binds in a sequence-dependent manner to peptide amyloids. The 3'-5' linked RNA backbone appears to be well-suited to support these interactions, with the phosphodiester backbone and nucleobases both contributing to the affinity. Sequence-specific RNA-peptide interactions of the kind identified here may provide a path to understanding one of the great mysteries rooted in the origin of life: the origin of the genetic code.

An Analysis of Nucleotide-Amyloid Interactions Reveals Selective Binding to Codon-Sized RNA.,Rout SK, Cadalbert R, Schroder N, Wang J, Zehnder J, Gampp O, Wiegand T, Guntert P, Klingler D, Kreutz C, Knorlein A, Hall J, Greenwald J, Riek R J Am Chem Soc. 2023 Oct 11;145(40):21915-21924. doi: 10.1021/jacs.3c06287. Epub , 2023 Oct 2. PMID:37782045^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rout SK, Cadalbert R, Schröder N, Wang J, Zehnder J, Gampp O, Wiegand T, Güntert P, Klingler D, Kreutz C, Knörlein A, Hall J, Greenwald J, Riek R. An Analysis of Nucleotide-Amyloid Interactions Reveals Selective Binding to Codon-Sized RNA. J Am Chem Soc. 2023 Oct 11;145(40):21915-21924. PMID:37782045 doi:10.1021/jacs.3c06287

1 Structural highlights
2 Publication Abstract from PubMed
3 References

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8pxs"

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[8pxs]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PXS FirstGlance]. <br>
-</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR, 10 models</td></tr>
 <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pxs OCA], [https://pdbe.org/8pxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pxs RCSB], [https://www.ebi.ac.uk/pdbsum/8pxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pxs ProSAT]</span></td></tr>

8pxs

From Proteopedia

Current revision

Short RNA binding to peptide amyloids

Structural highlights

Publication Abstract from PubMed

References

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