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| - | [[Image:1nig.gif|left|200px]] | |
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| - | <!--
| + | ==2.0 A Structure of Protein of Unknown Function from Thermoplasma acidophilum== |
| - | The line below this paragraph, containing "STRUCTURE_1nig", creates the "Structure Box" on the page.
| + | <StructureSection load='1nig' size='340' side='right'caption='[[1nig]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[1nig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NIG FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
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| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nig OCA], [https://pdbe.org/1nig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nig RCSB], [https://www.ebi.ac.uk/pdbsum/1nig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nig ProSAT], [https://www.topsan.org/Proteins/MCSG/1nig TOPSAN]</span></td></tr> |
| - | {{STRUCTURE_1nig| PDB=1nig | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | '''2.0 A Structure of Protein of Unknown Function from Thermoplasma acidophilum'''
| + | [https://www.uniprot.org/uniprot/Q9HIT9_THEAC Q9HIT9_THEAC] |
| - | | + | __TOC__ |
| - | | + | </StructureSection> |
| - | ==Overview== | + | [[Category: Large Structures]] |
| - | The crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum was solved with multiple-wavelength anomalous diffraction and refined at 2.0 A resolution. The molecule consists of a typical four-helix antiparallel bundle with overhand connection. However, its oligomerization into a trimer leads to a coiled "super-helix" which is novel for such bundles. Its central feature, a six-stranded coiled coil, is also novel for proteins. TA1238 does not have strong sequence homologues in databases, but shows strong structural similarity with some proteins in the Protein Data Bank. The function could not be inferred from the sequence but the structure, with some rearrangement, bears some resemblance to the active site region of cobalamin adenosyltransferase (TA1434). Specifically, TA1238 retains Arg104, which is structurally equivalent to functionally critical Arg119 of TA1434. For such conformational change, the overhand connection of TA1238 might need to be involved in a gating mechanism that might be modulated by ligands and/or by interactions with the physiological partners. This allowed us to hypothesize that TA1238 could be involved in cobalamin biosyntheses.
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| - | | + | |
| - | ==About this Structure== | + | |
| - | 1NIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIG OCA].
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| - | | + | |
| - | ==Reference== | + | |
| - | Crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum: a new type of helical super-bundle., Sanishvili R, Pennycooke M, Gu J, Xu X, Joachimiak A, Edwards AM, Christendat D, J Struct Funct Genomics. 2004;5(4):231-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15704011 15704011]
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| - | [[Category: Single protein]] | + | |
| | [[Category: Thermoplasma acidophilum]] | | [[Category: Thermoplasma acidophilum]] |
| - | [[Category: Christendat, D.]] | + | [[Category: Christendat D]] |
| - | [[Category: Edwards, A.]] | + | [[Category: Edwards A]] |
| - | [[Category: MCSG, Midwest Center for Structural Genomics.]]
| + | [[Category: Sanishvili R]] |
| - | [[Category: Sanishvili, R.]] | + | |
| - | [[Category: Four helixbundle]]
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| - | [[Category: Mcsg]]
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| - | [[Category: Midwest center for structural genomic]]
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| - | [[Category: Protein structure initiative]]
| + | |
| - | [[Category: Psi]]
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| - | [[Category: Structural genomic]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:34:28 2008''
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